GPCRs for ketone bodies and energy homeostasis
نویسندگان
چکیده
منابع مشابه
Role of ketone bodies in perinatal myocardial energy metabolism.
Metabolic changes at around the time of birth are crucial for life. Here we review the energy utilization in the myocardium, emphasizing ketone body metabolism. Before birth, glucose and lactate are the major energy substrates for the myocardium. Long-chain fatty acids (LCFA) are normally not available as an energy substrate for the fetal heart; however, when LCFA are supplied artificially in n...
متن کاملKetone bodies, potential therapeutic uses.
Ketosis, meaning elevation of D-beta-hydroxybutyrate (R-3hydroxybutyrate) and acetoacetate, has been central to starving man's survival by providing nonglucose substrate to his evolutionarily hypertrophied brain, sparing muscle from destruction for glucose synthesis. Surprisingly, D-beta-hydroxybutyrate (abbreviated "betaOHB") may also provide a more efficient source of energy for brain per uni...
متن کاملThe determination of ketone bodies.
Roche, J., Michel, R. & Jouan, P. (1957). Ciba Foundation Colloq. Endocrin. 10, 168. Rosenberg, I. N. (1951). J. clin. Inve8t. 30, 1. Schultz, A. L., Sandhaus, S., Demorest, H. L. & Zieve, L. (1954). J. clin. Endrocrin. 14, 1062. Sprott, W. E. & Maclagan, N. F. (1955). Biochem. J. 59,288. Taurog, A., Briggs, F. N. & Chaikoff, I. L. (1952). J. biol. Chem. 194, 655. Taurog, A., Chaikoff, I. L. & ...
متن کاملKetone bodies as signaling metabolites.
Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link the environment, in this case the diet, an...
متن کاملKetone Bodies Mediate Antiseizure Effects
Investigators from The Barrow Neurological Institute, Creighton University, University of Kentucky and the University of Calgary Faculty of Medicine investigated the effect of ketone bodies and the ketogenic diet on epileptic Kcna1-null mice.
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2020
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.93.0_1-s15-1